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Article

Depressive symptoms and cognitive decline in community-dwelling older adults.

Journal of the American Geriatrics Society - 1 May 2010

Köhler Sebastian, van Boxtel Martin P J, van Os Jim, Thomas Alan J, O'Brien John T, Jolles Jelle, Verhey Frans R J, Allardyce Judith

Abstract excerpt

OBJECTIVES: To examine the temporal association between depressive symptoms and cognitive functioning and estimate the effect measure modification of the apolipoprotein E (APOE) epsilon4 allele on this relationship. DESIGN: Prospective cohort study. SETTING: General community. PARTICIPANTS: Population-based sample of 598 cognitively intact older adults aged 60 and older, with re-assessments after 3 (N=479) and 6...

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Identifiers

PMID: 20374396
DOI: 10.1111/j.1532-5415.2010.02807.x

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APOE

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