Article
Apolipoprotein E and cognitive change in an elderly population.
Annals of neurology - 1 Jul 1996
Hyman B T, Gomez-Isla T, Briggs M, Chung H, Nichols S, Kohout F, Wallace R
Abstract excerpt
The apolipoprotein E (apoE) epsilon 4 allele is overrepresented, and the apoE epsilon 2 allele underrepresented, in Alzheimer's disease. To assess the risk of cognitive impairment in individuals with these genotypes in the general population, we studied a population-based sample of 1,899 individuals 65 years and older as a follow-up to the Iowa 65+ Rural Health Study. Multiple regression and logistic regression...
Topics
- Aged
- Alleles
- Alzheimer Disease
- Apolipoproteins E
- Brain
- Cholesterol, HDL
- Cognition Disorders
- Cross-Sectional Studies
- Female
- Genotype
- Humans
- Longitudinal Studies