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Article

Apolipoprotein epsilon4 allele status, depressive symptoms, and cognitive decline in middle-aged and elderly persons without dementia.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry - 1 Jan 2000

Lavretsky Helen, Ercoli Linda, Siddarth Prabha, Bookheimer Susan, Miller Karen, Small Gary

Abstract excerpt

OBJECTIVE: Because the apolipoprotein epsilon4 (APOE-epsilon4) allele or depressive symptoms may increase the risk for development of Alzheimer disease (AD), the authors assessed APOE-epsilon4 status, baseline level of depressive symptoms, and subsequent cognitive decline in middle-aged and older persons without dementia. METHODS: The 49 subjects (age range: 51-85 years) included 20 with and 29 without...

Topics

Aged
Aged, 80 and over
Alleles
Apolipoproteins E
Cognition Disorders
Dementia
Depression
Female
Follow-Up Studies
Genotype
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Neuropsychological Tests

Risk Factors

Severity of Illness Index

Source

Open in PubMed Open full text

Identifiers

PMID: 14609807
DOI: 10.1176/appi.ajgp.11.6.667
PMCID: PMC2810950

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-14609807-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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