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Article

APOE-epsilon4, depressive symptoms, and cognitive decline in Chinese older adults: Singapore Longitudinal Aging Studies.

The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Feb 2009

Niti Mathew, Yap Keng-Bee, Kua Ee-Heok, Ng Tze-Pin

Abstract excerpt

BACKGROUND: The precise relationship between depression and cognitive decline in older adults is unclear. We investigated the influence of apolipoprotein E (APOE)-epsilon4 genotype in modulating the effect of depressive symptoms on cognitive decline. METHODS: Prospective cohort study of 1,487 cognitively high-functioning Chinese older adults. Depressive symptoms (Geriatric Depression Scale score >/=5) and...

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Identifiers

PMID: 19181718
DOI: 10.1093/gerona/gln013
PMCID: PMC2655010

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APOE

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