Article
Genetic alterations of the p53 gene are a feature of malignant mesotheliomas.
Cancer research - 1 Oct 1991
Cote R J, Jhanwar S C, Novick S, Pellicer A
Abstract excerpt
A putative tumor suppressor gene, p53, has been shown to be altered in a variety of human tumor types. The primary mechanism of p53 inactivation is believed to be mutation of one allele followed by loss of the second allele. Malignant mesothelioma is a tumor that has been highly associated with exposure to asbestos fibers, which are known to cause chromosomal abnormalities in mesothelial cells. We have examined...
Topics
- Blotting, Northern
- Blotting, Southern
- Cell Line
- Chromosome Aberrations
- Chromosomes, Human, Pair 17
- DNA
- Gene Amplification
- Genes, p53
- Humans
- Karyotyping
- Mesothelioma
- Mutation