Article
Role and mutational heterogeneity of the p53 gene in hepatocellular carcinoma.
Cancer research - 15 Jan 1993
Nishida N, Fukuda Y, Kokuryu H, Toguchida J, Yandell D W, Ikenega M, Imura H, Ishizaki K
Abstract excerpt
The mutational spectrum of the p53 gene was analyzed in 53 hepatocellular carcinomas. Somatic mutations of the p53 gene were detected in 17 cases (32%). Among these 17 mutations, 9 were missense mutations; the mutations in the other 8 cases were nonsense mutations, deletions, or mutations at the...
Topics
- Base Sequence
- Carcinoma, Hepatocellular
- Chromosome Deletion
- Chromosome Mapping
- Chromosomes, Human, Pair 17
- Genes, p53
- Genetic Markers
- Humans
- Japan
- Liver Neoplasms
- Molecular Sequence Data
- Mutation
- Polymorphism, Restriction Fragment Length
- Tumor Suppressor Protein p53