Article
Role and mutational heterogeneity of the p53 gene in hepatocellular carcinoma.
Cancer research - 15 Jan 1993
Nishida N, Fukuda Y, Kokuryu H, Toguchida J, Yandell D W, Ikenega M, Imura H, Ishizaki K
Abstract excerpt
The mutational spectrum of the p53 gene was analyzed in 53 hepatocellular carcinomas. Somatic mutations of the p53 gene were detected in 17 cases (32%). Among these 17 mutations, 9 were missense mutations; the mutations in the other 8 cases were nonsense mutations, deletions, or mutations at the intron-exon junctions. These mutations were found in a wide region stretching from exon 4 to exon 10 without any single...
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