Article
Chromosome 17p deletions and p53 mutations in renal cell carcinoma.
Cancer research - 1 Jul 1993
Reiter R E, Anglard P, Liu S, Gnarra J R, Linehan W M
Abstract excerpt
Studies of the role of tumor suppressor genes in human renal cell carcinoma from our laboratory have suggested the presence of a disease gene(s) on the short arm of chromosome 3. Little is known about the role other tumor suppressor genes may play in this malignancy. Abnormalities of chromosome 17p and, in particular of p53, are common in many human malignancies. In order to evaluate the role of this region in...
Topics
- Base Sequence
- Blotting, Northern
- Carcinoma, Renal Cell
- Chromosome Deletion
- Chromosomes, Human, Pair 17
- DNA Probes
- DNA, Single-Stranded
- Genes, p53
- Heterozygote
- Humans
- Kidney Neoplasms
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Genetic
- RNA, Messenger
- Tumor Cells, Cultured