Article
p53 gene mutations in medulloblastoma. Immunohistochemistry, gel shift analysis, and sequencing.
Diagnostic molecular pathology : the American journal of surgical pathology, part B - 1 Mar 1993
Badiali M, Iolascon A, Loda M, Scheithauer B W, Basso G, Trentini G P, Giangaspero F
Abstract excerpt
Medulloblastoma (MB), the most common malignant tumor of the CNS in children, bears a loss of the short arm of chromosome 17 in almost half of the cases. The tumor suppressor gene p53 is located on this chromosome and its role in the pathogenesis of this primitive tumor is controversial. Twenty-t...
Topics
- Adolescent
- Adult
- Base Sequence
- Cerebellar Neoplasms
- Child
- Child, Preschool
- DNA, Neoplasm
- DNA, Single-Stranded
- Genes, p53
- Humans
- Infant
- Medulloblastoma
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Genetic