Article
Mutations of the p53 gene in lymphoid leukemia.
Blood - 15 Mar 1991
Sugimoto K, Toyoshima H, Sakai R, Miyagawa K, Hagiwara K, Hirai H, Ishikawa F, Takaku F
Abstract excerpt
p53 is currently considered to be a tumor suppressor gene product, and its alterations are suggested to be involved in several human malignancies. Here we show evidence of the possible involvement of p53 gene mutations in lymphoid leukemias studied by reverse transcriptase-polymerase chain reaction, single strand conformation polymorphism analysis, and nucleotide sequencing. Fourteen patients with various...
Topics
- Base Sequence
- Chromosome Deletion
- DNA
- DNA Mutational Analysis
- DNA Transposable Elements
- Gene Expression
- Genes, p53
- Humans
- Leukemia, Lymphoid
- Mutation
- Polymerase Chain Reaction