Article
Mutations in p53 as potential molecular markers for human breast cancer.
Proceedings of the National Academy of Sciences of the United States of America - 1 Dec 1991
Runnebaum I B, Nagarajan M, Bowman M, Soto D, Sukumar S
Abstract excerpt
Based on the high incidence of loss of heterozygosity for loci on chromosome 17p in the vicinity of the p53 locus in human breast tumors, we investigated the frequency and effects of mutations in the p53 tumor suppressor gene in mammary neoplasia. We examined the p53 gene in 20 breast cancer cell...
Topics
- Base Sequence
- Blotting, Northern
- Blotting, Southern
- Breast Neoplasms
- Cell Line
- Chromosomes, Human, Pair 17
- DNA, Neoplasm
- Female
- Genes, p53
- Genetic Markers
- Humans
- Molecular Sequence Data
- Mutation
- Oligodeoxyribonucleotides
- Polymerase Chain Reaction
- RNA, Messenger
- Tumor Suppressor Protein p53