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Article

p53 gene mutations and protein accumulation in human ovarian cancer.

1 Jun 1993

Abstract excerpt

Mutations of the p53 gene on chromosome 17p are a common genetic change in the malignant progression of many cancers. We have analyzed 38 malignant tumors of ovarian or peritoneal müllerian type for evidence of p53 variations at either the DNA or protein levels. Genetic studies were based on single-strand conformation polymorphism analysis and DNA sequencing of exons 2 through 11 of the p53 gene; mutations were...

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Identifiers

PMID: 8506342
DOI: 10.1073/pnas.90.11.4961

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Source receipt: pubmed, retrieved 7 Sept 2026.

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