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Article

Instability of immunoglobulin genes in S107 cell line.

Somatic cell and molecular genetics - 1 May 1991

Shin S U, DePinho R, Zack D J, Rudikoff S, Scharff M D

Abstract excerpt

Somatic mutation occurs frequently in rearranged and expressed immunoglobulin variable region genes in vivo. In contrast, V region hypermutation seldom occurs in antibody-forming cells in culture. The S107 mouse myeloma cell line is one of the few cell lines that has been observed to generate V region mutations frequently and spontaneously in vitro. Detailed examination reveals that both the S107 tumor and the...

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PMID: 1904631
DOI: 10.1007/BF01232821

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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