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Article

Instability of immunoglobulin genes in S107 cell line.

Somatic cell and molecular genetics - 1 May 1991

Shin S U, DePinho R, Zack D J, Rudikoff S, Scharff M D

Abstract excerpt

Somatic mutation occurs frequently in rearranged and expressed immunoglobulin variable region genes in vivo. In contrast, V region hypermutation seldom occurs in antibody-forming cells in culture. The S107 mouse myeloma cell line is one of the few cell lines that has been observed to generate V region mutations frequently and spontaneously in vitro. Detailed examination reveals that both the S107 tumor and the...

Topics

Animals
Base Sequence
Crossing Over, Genetic
Gene Rearrangement, B-Lymphocyte, Heavy Chain
Genes, Immunoglobulin
Immunoglobulin Constant Regions
Immunoglobulin Heavy Chains
Immunoglobulin Variable Region
Mice
Mice, Inbred BALB C

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Multigene Family

Mutation

RNA, Messenger

Tumor Cells, Cultured

Source

Identifiers

PMID: 1904631
DOI: 10.1007/BF01232821

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1904631-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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