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Article

Clonal instability of V region hypermutation in the Ramos Burkitt's lymphoma cell line.

International immunology - 1 Sept 2001

Zhang W, Bardwell P D, Woo C J, Poltoratsky V, Scharff M D, Martin A

Abstract excerpt

Affinity maturation of the humoral immune response is caused by single base changes that are introduced into the V regions of the Ig genes during a brief period of B cell differentiation. It has recently become possible to study V region mutation in some human Burkitt's lymphoma cell lines that mutate their V regions and express surface markers that suggest they arose from the malignant transformation of germinal...

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PMID: 11526098
DOI: 10.1093/intimm/13.9.1175

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Clonal instability of V region hypermutation in the Ramos Burkitt's lymphoma cell line.PMID 11526098Read ↗

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