Article
Deletion of Rb1 induces both hyperproliferation and cell death in murine germinal center B cells.
Experimental hematology - 1 Mar 2016
He Zhiwen, O'Neal Julie, Wilson William C, Mahajan Nitin, Luo Jun, Wang Yinan, Su Mack Y, Lu Lan, Skeath James B, Bhattacharya Deepta, Tomasson Michael H
Abstract excerpt
The retinoblastoma gene (RB1) has been implicated as a tumor suppressor in multiple myeloma (MM), yet its role remains unclear because in the majority of cases with 13q14 deletions, un-mutated RB1 remains expressed from the retained allele. To explore the role of Rb1 in MM, we examined the functional consequences of single- and double-copy Rb1 loss in germinal center B cells, the cells of origin of MM. We...
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