Article
Comparison of somatic mutation frequency among immunoglobulin genes.
The Journal of experimental medicine - 1 Feb 1994
Motoyama N, Miwa T, Suzuki Y, Okada H, Azuma T
Abstract excerpt
We analyzed the frequency of somatic mutation in immunoglobulin genes from hybridomas that secrete anti-(4-hydroxy-3-nitrophenyl)acetyl (NP) monoclonal antibodies. A high frequency of mutation (3.3-4.4%) was observed in both the rearranged VH186.2 and V lambda 1 genes, indicating that somatic mut...
Topics
- Animals
- Base Sequence
- DNA
- Gene Rearrangement, B-Lymphocyte
- Genes, Immunoglobulin
- Hybridomas
- Immunoglobulin Variable Region
- Immunoglobulin lambda-Chains
- Mice
- Mice, Inbred C57BL
- Molecular Sequence Data
- Mutation
- Promoter Regions, Genetic
- Sequence Homology, Nucleic Acid