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Article

Comparison of somatic mutation frequency among immunoglobulin genes.

The Journal of experimental medicine - 1 Feb 1994

Motoyama N, Miwa T, Suzuki Y, Okada H, Azuma T

Abstract excerpt

We analyzed the frequency of somatic mutation in immunoglobulin genes from hybridomas that secrete anti-(4-hydroxy-3-nitrophenyl)acetyl (NP) monoclonal antibodies. A high frequency of mutation (3.3-4.4%) was observed in both the rearranged VH186.2 and V lambda 1 genes, indicating that somatic mutation occurs with similar frequency in these genes in spite of the absence of an intron enhancer in lambda 1 chain...

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Identifiers

PMID: 8294856
DOI: 10.1084/jem.179.2.395
PMCID: PMC2191348

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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