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Article

Immunoglobulin hypermutation in cultured cells.

Immunological reviews - 1 Apr 1998

Green N S, Lin M M, Scharff M D

Abstract excerpt

Studies of endogenous and engineered Ig genes in mice have begun to reveal some of the cis-acting regions that are involved in the somatic hypermutation of variable regions in vivo. These studies suggest that the initiation of transcription plays a role in this process. However, it will be difficult to identify and manipulate the individual genetic elements and the trans-acting proteins that regulate and target...

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Source

Identifiers

PMID: 9602354
DOI: 10.1111/j.1600-065x.1998.tb01431.x

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Source receipt: pubmed, retrieved 7 Sept 2026.

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