Article
Hypermutation of immunoglobulin genes in memory B cells of DNA repair-deficient mice.
The Journal of experimental medicine - 1 Jun 1998
Jacobs H, Fukita Y, van der Horst G T, de Boer J, Weeda G, Essers J, de Wind N, Engelward B P, Samson L, Verbeek S, de Murcia J M, de Murcia G, te Riele H, Rajewsky K
Abstract excerpt
To investigate the possible involvement of DNA repair in the process of somatic hypermutation of rearranged immunoglobulin variable (V) region genes, we have analyzed the occurrence, frequency, distribution, and pattern of mutations in rearranged Vlambda1 light chain genes from naive and memory B cells in DNA repair-deficient mutant mouse strains. Hypermutation was found unaffected in mice carrying mutations in...
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