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Article

Instability of chimaeric antibody secretion by anti-carcinoembryonic antigen producing hybridoma cells after gene targeting.

Medical principles and practice : international journal of the Kuwait University, Health Science Centre - 1 Jan 2005

El-Abdallah Abir A, Ford Christopher H J

Abstract excerpt

OBJECTIVE: To produce a chimaeric version of the 11-285-14 anti-carcinoembryonic antigen (CEA) monoclonal antibody using a gene targeting approach. MATERIALS AND METHODS: A replacement vector was constructed to insert the human constant gamma1 gene within the mouse heavy chain locus of 11-285-14 hybridoma cells. The mouse constant gamma1 gene (1.5 kb) and the mouse mu intron fragment (2.2 kb) were amplified by...

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Identifiers

PMID: 16103718
DOI: 10.1159/000086189

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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