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Article

Mapping the upstream boundary of somatic mutations in rearranged immunoglobulin transgenes and endogenous genes.

Molecular immunology - 1 Feb 1994

Rogerson B J

Abstract excerpt

Mammalian B-cell specific somatic hypermutation contributes to affinity maturation of the antibody response. This mutator activity is highly focused on rearranged immunoglobulin variable regions, but the underlying mechanism remains to be elucidated. In an effort to gain insights into the mechanism of somatic hypermutation, the precise distribution and frequency of mutations upstream of murine immunoglobulin...

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PMID: 8309480
DOI: 10.1016/0161-5890(94)90081-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Mapping the upstream boundary of somatic mutations in rearranged immunoglobulin transgenes and endogenous genes.PMID 8309480Read ↗

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