Mapping the upstream boundary of somatic mutations in rearranged immunoglobulin transgenes and endogenous genes.

doi:10.1016/0161-5890(94)90081-7

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Article

Mapping the upstream boundary of somatic mutations in rearranged immunoglobulin transgenes and endogenous genes.

Molecular immunology - 1 Feb 1994

Rogerson B J

Abstract excerpt

Mammalian B-cell specific somatic hypermutation contributes to affinity maturation of the antibody response. This mutator activity is highly focused on rearranged immunoglobulin variable regions, but the underlying mechanism remains to be elucidated. In an effort to gain insights into the mechanism of somatic hypermutation, the precise distribution and frequency of mutations upstream of murine immunoglobulin...

Topics

Animals
Base Sequence
Chromosome Mapping
DNA
Gene Rearrangement, B-Lymphocyte
Genes, Immunoglobulin
Immunoglobulin Heavy Chains
Immunoglobulin Variable Region
Immunoglobulin kappa-Chains
Introns
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred BALB C

Mice, Inbred C57BL

Mice, Transgenic

Molecular Sequence Data

Mutation

Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 8309480
DOI: 10.1016/0161-5890(94)90081-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8309480-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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