Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Somatic hypermutation of VHS107 genes is not associated with gene conversion among family members.

International immunology - 1 Aug 1995

Rogerson B J

Abstract excerpt

Murine B cells proliferating in the germinal centers of peripheral lymphoid tissue accumulate mutations in their rearranged variable regions, a diversification process which contributes to affinity maturation of the antibody response. The highly targeted nature of the hypermutation process could be explained by a somatic gene conversion mechanism. Well characterized examples of such an activity in B cells are...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Cloning, Molecular
Share to Gene Frequency

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mice, Transgenic

Share to Molecular Sequence Data

Share to Mutation

Share to Point Mutation

Source

Identifiers

PMID: 7495729
DOI: 10.1093/intimm/7.8.1225

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Somatic hypermutation of VHS107 genes is not associated with gene conversion among family members.PMID 7495729Read ↗

Mapping the upstream boundary of somatic mutations in rearranged immunoglobulin transgenes and endogenous genes.Semantic proximity Read ↗

Diversification of rabbit VH genes by gene-conversion-like and hypermutation mechanisms.Semantic proximity Read ↗

Gene conversion and hypermutation during diversification of VH sequences in developing splenic germinal centers of immunized rabbits.Semantic proximity Read ↗

A New Model of Sheep Ig Diversification: Shifting the Emphasis Toward Combinatorial Mechanisms and Away from HypermutationSemantic proximity Read ↗

Somatic hypermutation in normal and transformed human B cells.Semantic proximity Read ↗

Receptor Revision of Immunoglobulin Heavy Chain Variable Region Genes in Normal Human B LymphocytesSemantic proximity Read ↗

Somatic hypermutation in 5' flanking regions of heavy chain antibody variable regions.Semantic proximity Read ↗

Bovine IgG repertoire is dominated by a single diversified VH gene familySemantic proximity Read ↗

Comparison of somatic mutation frequency among immunoglobulin genes.Semantic proximity Read ↗

Analysis of patterns of DNA sequence variation in flanking and coding regions of murine germ-line immunoglobulin heavy-chain variable genes: evolutionary implications.Semantic proximity Read ↗

Instability of immunoglobulin genes in S107 cell line.Semantic proximity Read ↗

Distribution of mutations around rearranged heavy-chain antibody variable-region genes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.