Article
Somatic hypermutation of VHS107 genes is not associated with gene conversion among family members.
International immunology - 1 Aug 1995
Rogerson B J
Abstract excerpt
Murine B cells proliferating in the germinal centers of peripheral lymphoid tissue accumulate mutations in their rearranged variable regions, a diversification process which contributes to affinity maturation of the antibody response. The highly targeted nature of the hypermutation process could...
Topics
- Animals
- B-Lymphocyte Subsets
- Base Sequence
- Cell Separation
- Cloning, Molecular
- Gene Conversion
- Gene Frequency
- Germinal Center
- Immunoglobulin Heavy Chains
- Immunoglobulin Variable Region
- Mice
- Mice, Transgenic
- Molecular Sequence Data
- Multigene Family
- Mutation
- Point Mutation