Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CpG island methylator phenotype associates with low-degree chromosomal abnormalities in colorectal cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Oct 2008

Cheng Yu-Wei, Pincas Hanna, Bacolod Manny D, Schemmann Gunter, Giardina Sarah F, Huang Jianmin, Barral Sandra, Idrees Kamran, Khan Sajid A, Zeng Zhaoshi, Rosenberg Shoshana, Notterman Daniel A, Ott Jurg, Paty Philip, Barany Francis

Abstract excerpt

PURPOSE: Aberrant promoter methylation and genomic instability occur frequently during colorectal cancer development. CpG island methylator phenotype (CIMP) has been shown to associate with microsatellite instability, and BRAF mutation and is often found in the right-side colon. Nevertheless, the relative importance of CIMP and chromosomal instability (CIN) for tumorigenesis has yet to be thoroughly investigated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomal Instability
Share to Chromosome Aberrations

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Colorectal Neoplasms

Share to CpG Islands

Share to DNA Methylation

Share to Epigenesis, Genetic

Share to Genome, Human

Share to Proto-Oncogene Proteins B-raf

Source

Open in PubMed Open full text

Identifiers

PMID: 18829479
DOI: 10.1158/1078-0432.CCR-08-0216
PMCID: PMC3268558

Genes

BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CpG island methylator phenotype associates with low-degree chromosomal abnormalities in colorectal cancer.PMID 18829479Read ↗

CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer.Semantic proximity Read ↗

The CpG island methylator phenotype in colorectal cancer: progress and problems.Semantic proximity Read ↗

CpG island methylator phenotype (CIMP) of colorectal cancer is best characterised by quantitative DNA methylation analysis and prospective cohort studies.Semantic proximity Read ↗

The methylator phenotype in microsatellite stable colorectal cancers is characterized by a distinct gene expression profile.Semantic proximity Read ↗

CpG Island Methylator Phenotype-A Hope for the Future or a Road to Nowhere?Semantic proximity Read ↗

Aberrant DNA methylation patterns in microsatellite stable human colorectal cancers define a new marker panel for the CpG island methylator phenotype.Semantic proximity Read ↗

The role of the CpG island methylator phenotype in colorectal cancer prognosis depends on microsatellite instability screening status.Semantic proximity Read ↗

Comprehensive biostatistical analysis of CpG island methylator phenotype in colorectal cancer using a large population-based sample.Semantic proximity Read ↗

Epigenetic alterations in colorectal cancer: the CpG island methylator phenotype.Semantic proximity Read ↗

A novel classification of colorectal tumors based on microsatellite instability, the CpG island methylator phenotype and chromosomal instability: implications for prognosis.Semantic proximity Read ↗

Chromosomally and microsatellite stable colorectal carcinomas without the CpG island methylator phenotype in a molecular classification.Semantic proximity Read ↗

CpG island methylator phenotype-low (CIMP-low) in colorectal cancer: possible associations with male sex and KRAS mutations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.