Article
CpG island methylator phenotype (CIMP) of colorectal cancer is best characterised by quantitative DNA methylation analysis and prospective cohort studies.
Gut - 1 Jul 2006
Ogino S, Cantor M, Kawasaki T, Brahmandam M, Kirkner G J, Weisenberger D J, Campan M, Laird P W, Loda M, Fuchs C S
Abstract excerpt
BACKGROUND: The concept of CpG island methylator phenotype (CIMP) is not universally accepted. Even if specific clinicopathological features have been associated with CIMP, investigators often failed to demonstrate a bimodal distribution of the number of methylated markers, which would suggest CI...
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