Article
The methylator phenotype in microsatellite stable colorectal cancers is characterized by a distinct gene expression profile.
The Journal of pathology - 1 Apr 2008
Ferracin M, Gafà R, Miotto E, Veronese A, Pultrone C, Sabbioni S, Lanza G, Negrini M
Abstract excerpt
The CpG island methylator phenotype (CIMP) in colorectal tumours can be recognized by an increased frequency of aberrant methylation in a specific set of genomic loci. Because of the strong association of CIMP with high microsatellite instability (MSI-H), the identification of CIMP+ tumours within microsatellite stable (MSS) colorectal cancers may not be straightforward. To overcome this potential limitation, we...
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