Article
A novel classification of colorectal tumors based on microsatellite instability, the CpG island methylator phenotype and chromosomal instability: implications for prognosis.
Annals of oncology : official journal of the European Society for Medical Oncology - 1 Aug 2013
Simons C C J M, Hughes L A E, Smits K M, Khalid-de Bakker C A, de Bruïne A P, Carvalho B, Meijer G A, Schouten L J, van den Brandt P A, Weijenberg M P, van Engeland M
Abstract excerpt
BACKGROUND: We studied the overlap between the major (epi)genomic events microsatellite instability (MSI), the CpG island methylator phenotype (CIMP) and chromosomal instability (CIN) in colorectal cancer (CRC), and whether specific (epi)genotypes were associated with CRC-related deaths. PATIENTS AND METHODS: Molecular analyses using tumor DNA were successful in 509 CRC cases identified within the Netherlands...
Topics
- Aged
- Chromosomal Instability
- Colorectal Neoplasms
- CpG Islands
- DNA Methylation
- Female
- Genotype
- Humans
- Male
- Microsatellite Instability