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Article

CpG island methylator phenotype-low (CIMP-low) in colorectal cancer: possible associations with male sex and KRAS mutations.

The Journal of molecular diagnostics : JMD - 1 Nov 2006

Ogino Shuji, Kawasaki Takako, Kirkner Gregory J, Loda Massimo, Fuchs Charles S

Abstract excerpt

The CpG island methylator phenotype (CIMP or CIMP-high) with extensive promoter methylation seems to be a distinct epigenotype of colorectal cancer. However, no study has comprehensively examined features of colorectal cancer with less extensive promoter methylation (designated as "CIMP-low"). Using real-time polymerase chain reaction (MethyLight), we quantified DNA methylation in five CIMP-specific gene...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to DNA, Neoplasm

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Source

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Identifiers

PMID: 17065427
DOI: 10.2353/jmoldx.2006.060082
PMCID: PMC1876166

Genes

KRAS
BRAF
CRABP1
MLH1
NEUROG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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