Article
Aberrant DNA methylation patterns in microsatellite stable human colorectal cancers define a new marker panel for the CpG island methylator phenotype.
International journal of cancer - 15 Feb 2022
Gebhard Claudia, Mulet-Lazaro Roger, Glatz Dagmar, Schwarzfischer-Pfeilschifter Lucia, Schirmacher Peter, Gaedcke Jochen, Weichert Wilko, Reuschel Edith, Dietmaier Wolfgang, Rehli Michael
Abstract excerpt
A distinct group of colorectal carcinomas (CRCs) referred to as the "CpG island methylator phenotype" (CIMP) shows an extremely high incidence of de novo DNA methylation and may share common pathological, clinical or molecular features. However, there is limited consensus about which CpG islands (CGIs) define a CIMP, particularly in microsatellite stable (MSS) carcinomas. To study this phenotype in a systematic...
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