Article
The role of the CpG island methylator phenotype in colorectal cancer prognosis depends on microsatellite instability screening status.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Mar 2010
Dahlin Anna M, Palmqvist Richard, Henriksson Maria L, Jacobsson Maria, Eklöf Vincy, Rutegård Jörgen, Oberg Ake, Van Guelpen Bethany R
Abstract excerpt
PURPOSE: The aim of this study was to relate the CpG island methylator phenotype (CIMP; characterized by extensive promoter hypermethylation) to cancer-specific survival in colorectal cancer, taking into consideration relevant clinicopathologic factors, such as microsatellite instability (MSI) screening status and the BRAF V600E mutation. EXPERIMENTAL DESIGN: Archival tumor samples from 190 patients from the...
Topics
- Adult
- Aged
- Colorectal Neoplasms
- CpG Islands
- DNA Methylation
- Female
- Gene Expression Regulation, Neoplastic
- Humans
- Immunoenzyme Techniques
- Male
- Microsatellite Instability
- Middle Aged
- Mutation