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Article

CpG Island Methylator Phenotype-A Hope for the Future or a Road to Nowhere?

International journal of molecular sciences - 13 Jan 2022

Paweł Karpiński, Maria Małgorzata Sąsiadek

Abstract excerpt

The CpG island methylator phenotype (CIMP) can be regarded as the most notable emanation of epigenetic instability in cancer. Since its discovery in the late 1990s, CIMP has been extensively studied, mainly in colorectal cancers (CRC) and gliomas. Consequently, knowledge on molecular and pathological characteristics of CIMP in CRC and other tumour types has rapidly expanded. Concordant and widespread...

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Identifiers

PMID: 35055016
DOI: 10.3390/ijms23020830
PMCID: PMC8777692

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