Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Comprehensive biostatistical analysis of CpG island methylator phenotype in colorectal cancer using a large population-based sample.

PloS one - 1 Jan 2008

Nosho Katsuhiko, Irahara Natsumi, Shima Kaori, Kure Shoko, Kirkner Gregory J, Schernhammer Eva S, Hazra Aditi, Hunter David J, Quackenbush John, Spiegelman Donna, Giovannucci Edward L, Fuchs Charles S, Ogino Shuji

Abstract excerpt

BACKGROUND: The CpG island methylator phenotype (CIMP) is a distinct phenotype associated with microsatellite instability (MSI) and BRAF mutation in colon cancer. Recent investigations have selected 5 promoters (CACNA1G, IGF2, NEUROG1, RUNX3 and SOCS1) as surrogate markers for CIMP-high. However, no study has comprehensively evaluated an expanded set of methylation markers (including these 5 markers) using a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CpG Islands
Share to Data Interpretation, Statistical

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Methylation

Share to Microsatellite Instability

Share to Proto-Oncogene Proteins

Share to Proto-Oncogene Proteins B-raf

Share to Proto-Oncogene Proteins p21(ras)

Share to ras Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 19002263
DOI: 10.1371/journal.pone.0003698
PMCID: PMC2579485

Genes

BRAF
KRAS
CRABP1
IGF2
MLH1
NEUROG1
RUNX3
SOCS1
WRN
CHFR
CTNNB1
HIC1
IGFBP3
MGMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Comprehensive biostatistical analysis of CpG island methylator phenotype in colorectal cancer using a large population-based sample.PMID 19002263Read ↗

Evaluation of markers for CpG island methylator phenotype (CIMP) in colorectal cancer by a large population-based sample.Semantic proximity Read ↗

CpG island methylator phenotype, microsatellite instability, BRAF mutation and clinical outcome in colon cancer.Semantic proximity Read ↗

Epidemiology and Molecular-Pathologic Characteristics of CpG Island Methylator Phenotype (CIMP) in Colorectal Cancer.Semantic proximity Read ↗

Comprehensive profiling of DNA methylation in colorectal cancer reveals subgroups with distinct clinicopathological and molecular features.Semantic proximity Read ↗

Hypermethylator phenotype in sporadic colon cancer: study on a population-based series of 582 cases.Semantic proximity Read ↗

CpG island methylator phenotype (CIMP) of colorectal cancer is best characterised by quantitative DNA methylation analysis and prospective cohort studies.Semantic proximity Read ↗

CpG island methylator phenotype in colorectal cancers: comparison of the new and classic CpG island methylator phenotype marker panels.Semantic proximity Read ↗

Evaluation of a large, population-based sample supports a CpG island methylator phenotype in colon cancer.Semantic proximity Read ↗

CpG island methylator phenotype-low (CIMP-low) in colorectal cancer: possible associations with male sex and KRAS mutations.Semantic proximity Read ↗

The methylator phenotype in microsatellite stable colorectal cancers is characterized by a distinct gene expression profile.Semantic proximity Read ↗

CpG island methylator phenotype identifies high risk patients among microsatellite stable BRAF mutated colorectal cancers.Semantic proximity Read ↗

CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.