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Article

Caprin-2 enhances canonical Wnt signaling through regulating LRP5/6 phosphorylation.

The Journal of cell biology - 8 Sept 2008

Ding Yu, Xi Ying, Chen Ting, Wang Ji-yong, Tao Dong-lei, Wu Zhi-Li, Li Yi-ping, Li Chen, Zeng Rong, Li Lin

Abstract excerpt

The low-density lipoprotein receptor-related proteins 5 and 6 (LRP5/6) are coreceptors for Frizzled and transmit signals from the plasma membrane to the cytosol. However, the mechanism for LRP5/6 signal transmission remains undefined. Here, we identify cytoplasmic activation/proliferation-associated protein 2 (Caprin-2) as a LRP5/6-binding protein. Our data show that Caprin-2 stabilizes cytosolic beta-catenin and...

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Identifiers

PMID: 18762581
DOI: 10.1083/jcb.200803147
PMCID: PMC2528581

Genes

LRP5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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