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Article

Makorin-2 is a neurogenesis inhibitor downstream of phosphatidylinositol 3-kinase/Akt (PI3K/Akt) signal.

The Journal of biological chemistry - 28 Mar 2008

Yang Pai-Hao, Cheung William K C, Peng Ying, He Ming-Liang, Wu Guo-Qing, Xie Dan, Jiang Bing-Hua, Huang Qiu-Hua, Chen Zhu, Lin Marie C M, Kung Hsiang-Fu

Abstract excerpt

Makorin-2 belongs to the makorin RING zinc finger gene family, which encodes putative ribonucleoproteins. Here we cloned the Xenopus makorin-2 (mkrn2) and characterized its function in Xenopus neurogenesis. Forced overexpression of mkrn2 produced tadpoles with dorso-posterior deficiencies and small-head/short-tail phenotype, whereas knockdown of mkrn2 by morpholino antisense oligonucleotides induced double axis...

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Identifiers

PMID: 18198183
DOI: 10.1074/jbc.M704768200
PMCID: PMC2417189

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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