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Article

Down syndrome critical region protein 5 regulates membrane localization of Wnt receptors, Dishevelled stability and convergent extension in vertebrate embryos.

Development (Cambridge, England) - 1 Jun 2009

Shao Ming, Liu Zhong-Zhen, Wang Cheng-Dong, Li Hong-Yan, Carron Clémence, Zhang Hong-Wei, Shi De-Li

Abstract excerpt

The Glypican family of heparan sulfate proteoglycans regulates Wnt signaling and convergent extension (CE) in vertebrate embryos. They are predicted to be glycosylphosphatidylinositol (GPI)-tethered membrane-bound proteins, but there is no functional evidence of their regulation by the GPI synthesis complex. Down syndrome critical region protein 5 (Dscr5, also known as Pigp) is a component of the...

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PMID: 19465602
DOI: 10.1242/dev.032649

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GPI

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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