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Article

Structural insights into the C1q domain of Caprin-2 in canonical Wnt signaling.

The Journal of biological chemistry - 5 Dec 2014

Miao Haofei, Jia Yingying, Xie Sichun, Wang Xin, Zhao Jianfei, Chu Youjun, Zhou Zhilei, Shi Zhubing, Song Xiaomin, Li Lin

Abstract excerpt

Previously, we have identified Caprin-2 as a new regulator in canonical Wnt signaling through a mechanism of facilitating LRP5/6 phosphorylation; moreover, we found that its C-terminal C1q-related domain (Cap2_CRD) is required for this process. Here, we determined the crystal structures of Cap2_CRD from human and zebrafish, which both associate as a homotrimer with calcium located at the symmetric center....

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Share to Calcium
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Crystallography, X-Ray

Share to Protein Multimerization

Share to Protein Structure, Secondary

Share to RNA-Binding Proteins

Share to Wnt Signaling Pathway

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Source

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Identifiers

PMID: 25331957
DOI: 10.1074/jbc.M114.591636
PMCID: PMC4256344

Genes

LRP5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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