Article
The extracellular domain of Lrp5/6 inhibits noncanonical Wnt signaling in vivo.
Molecular biology of the cell - 1 Feb 2009
Bryja Vitezslav, Andersson Emma R, Schambony Alexandra, Esner Milan, Bryjová Lenka, Biris Kristin K, Hall Anita C, Kraft Bianca, Cajanek Lukas, Yamaguchi Terry P, Buckingham Margaret, Arenas Ernest
Abstract excerpt
Lrp5/6 are crucial coreceptors for Wnt/beta-catenin signaling, a pathway biochemically distinct from noncanonical Wnt signaling pathways. Here, we examined the possible participation of Lrp5/6 in noncanonical Wnt signaling. We found that Lrp6 physically interacts with Wnt5a, but that this does not lead to phosphorylation of Lrp6 or activation of the Wnt/beta-catenin pathway. Overexpression of Lrp6 blocks...
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