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Article

Zebrafish Dpr2 inhibits mesoderm induction by promoting degradation of nodal receptors.

Science (New York, N.Y.) - 1 Oct 2004

Zhang Lixia, Zhou Hu, Su Ying, Sun Zhihui, Zhang Haiwen, Zhang Long, Zhang Yu, Ning Yuanheng, Chen Ye-Guang, Meng Anming

Abstract excerpt

Nodal proteins, members of the transforming growth factor-beta (TGFbeta) superfamily, have been identified as key endogenous mesoderm inducers in vertebrates. Precise control of Nodal signaling is essential for normal development of embryos. Here, we report that zebrafish dapper2 (dpr2) is expressed in mesoderm precursors during early embryogenesis and is positively regulated by Nodal signals. In vivo functional...

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Identifiers

PMID: 15459392
DOI: 10.1126/science.1100569

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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