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Article

Pygopus and Legless target Armadillo/beta-catenin to the nucleus to enable its transcriptional co-activator function.

Nature cell biology - 1 Jul 2004

Townsley Fiona M, Cliffe Adam, Bienz Mariann

Abstract excerpt

Wnt signalling controls the transcription of genes that function during normal and malignant development. Stimulation by canonical Wnt ligands activates beta-catenin (or Drosophila melanogaster Armadillo) by blocking its phosphorylation, resulting in its stabilization and translocation to the nucleus. Here, Armadillo/beta-catenin binds to TCF/LEF transcription factors and recruits chromatin-modifying and...

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PMID: 15208637
DOI: 10.1038/ncb1141

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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