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Article

Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A.

Science (New York, N.Y.) - 26 Mar 1999

Seeling J M, Miller J R, Gil R, Moon R T, White R, Virshup D M

Abstract excerpt

Dysregulation of Wnt-beta-catenin signaling disrupts axis formation in vertebrate embryos and underlies multiple human malignancies. The adenomatous polyposis coli (APC) protein, axin, and glycogen synthase kinase 3beta form a Wnt-regulated signaling complex that mediates the phosphorylation-dependent degradation of beta-catenin. A protein phosphatase 2A (PP2A) regulatory subunit, B56, interacted with APC in the...

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Source

Identifiers

PMID: 10092233
DOI: 10.1126/science.283.5410.2089

Genes

APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A.PMID 10092233Read ↗

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