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Article

HSP105 recruits protein phosphatase 2A to dephosphorylate β-catenin.

Molecular and cellular biology - 1 Apr 2015

Yu Nancy, Kakunda Michael, Pham Victoria, Lill Jennie R, Du Pan, Wongchenko Matthew, Yan Yibing, Firestein Ron, Huang XiaoDong

Abstract excerpt

The Wnt/β-catenin pathway causes accumulation of β-catenin in the cytoplasm and its subsequent translocation into the nucleus to initiate the transcription of the target genes. Without Wnt stimulation, β-catenin forms a complex with axin (axis inhibitor), adenomatous polyposis coli (APC), casein kinase 1α (CK1α), and glycogen synthase kinase 3β (GSK3β) and undergoes phosphorylation-dependent ubiquitination....

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Identifiers

PMID: 25645927
DOI: 10.1128/MCB.01307-14
PMCID: PMC4372692

Genes

APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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