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Article

Nuclear translocation of β-catenin in Wg/Wnt signaling via the IFT-A microtubule-associated complex requires Pasovec/Gid8 proteins.

Science advances - 3 Apr 2026

Vuong Linh T, Mlodzik Marek

Abstract excerpt

Wg/Wnt signaling is critical throughout development and homeostasis and associated with many diseases, including cancer. Wg/Wnt signaling is mediated by β-catenin (Armadillo/Arm in Drosophila) with the IFT-A/Kinesin2 complex promoting nuclear translocation of β-catenin/Arm. Existing information suggests that additional proteins are involved. Here, we demonstrate that a conserved protein, Pasovec (Psv; Gid8 in...

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Identifiers

PMID: 41931626
DOI: 10.1126/sciadv.aea3382
PMCID: PMC13048246

Genes

IFT140

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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