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Article

Clinical risk factors, DNA variants, and the development of type 2 diabetes.

The New England journal of medicine - 20 Nov 2008

Lyssenko Valeriya, Jonsson Anna, Almgren Peter, Pulizzi Nicoló, Isomaa Bo, Tuomi Tiinamaija, Berglund Göran, Altshuler David, Nilsson Peter, Groop Leif

Abstract excerpt

BACKGROUND: Type 2 diabetes mellitus is thought to develop from an interaction between environmental and genetic factors. We examined whether clinical or genetic factors or both could predict progression to diabetes in two prospective cohorts. METHODS: We genotyped 16 single-nucleotide polymorphisms (SNPs) and examined clinical factors in 16,061 Swedish and 2770 Finnish subjects. Type 2 diabetes developed in 2201...

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Source

Identifiers

PMID: 19020324
DOI: 10.1056/NEJMoa0801869

Genes

CDKAL1
FTO
HHEX
JAZF1
KCNJ11
NOTCH2
PPARG
WFS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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