Genome-Wide Association Analysis of Pancreatic Beta-Cell Glucose Sensitivity.

doi:10.1210/clinem/dgaa653

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Article

Genome-Wide Association Analysis of Pancreatic Beta-Cell Glucose Sensitivity.

The Journal of clinical endocrinology and metabolism - 1 Jan 2021

Deshmukh Harshal A, Madsen Anne Lundager, Viñuela Ana, Have Christian Theil, Grarup Niels, Tura Andrea, Mahajan Anubha, Heggie Alison J, Koivula Robert W, De Masi Federico, Tsirigos Konstantinos K, Linneberg Allan, Drivsholm Thomas, Pedersen Oluf, Sørensen Thorkild I A, Astrup Arne, Gjesing Anette A P, Pavo Imre, Wood Andrew R, Ruetten Hartmut, Jones Angus G, Koopman Anitra D M, Cederberg Henna, Rutters Femke, Ridderstrale Martin, Laakso Markku, McCarthy Mark I, Frayling Tim M, Ferrannini Ele, Franks Paul W, Pearson Ewan R, Mari Andrea, Hansen Torben, Walker Mark

Abstract excerpt

CONTEXT: Pancreatic beta-cell glucose sensitivity is the slope of the plasma glucose-insulin secretion relationship and is a key predictor of deteriorating glucose tolerance and development of type 2 diabetes. However, there are no large-scale studies looking at the genetic determinants of beta-cell glucose sensitivity. OBJECTIVE: To understand the genetic determinants of pancreatic beta-cell glucose sensitivity...

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Identifiers

PMID: 32944759
DOI: 10.1210/clinem/dgaa653
PMCID: PMC7765651

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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