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Article

Association between insulin secretion, insulin sensitivity and type 2 diabetes susceptibility variants identified in genome-wide association studies.

Acta diabetologica - 1 Sept 2009

Ruchat Stephanie-May, Elks Cathy E, Loos Ruth J F, Vohl Marie-Claude, Weisnagel S John, Rankinen Tuomo, Bouchard Claude, Pérusse Louis

Abstract excerpt

Several single nucleotide polymorphisms (SNPs) for type 2 diabetes mellitus (T2DM) risk have been identified by genome wide association studies (GWAS). The objective of the present study was to investigate the impact of these SNPs on T2DM intermediate phenotypes in order to clarify the physiological mechanisms through which they exert their effects on disease etiology. We analysed 23 SNPs in 9 T2DM genes (CDKAL1,...

Topics

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Blood Glucose
Diabetes Mellitus, Type 2
Genome-Wide Association Study
Glucose Tolerance Test
Insulin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Insulin-Secreting Cells

Insulin Secretion

Source

Identifiers

PMID: 19082521
DOI: 10.1007/s00592-008-0080-5

Genes

CDKAL1
HHEX
IDE
KCNJ11
WFS1

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