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Article

Dissecting the role of p53 phosphorylation in homologous recombination provides new clues for gain-of-function mutants.

Nucleic acids research - 1 Sept 2008

Restle Anja, Färber Martin, Baumann Cindy, Böhringer Michael, Scheidtmann Karl Heinz, Müller-Tidow Carsten, Wiesmüller Lisa

Abstract excerpt

Regulation of homologous recombination (HR) represents the best-characterized DNA repair function of p53. The role of p53 phosphorylation in DNA repair is largely unknown. Here, we show that wild-type p53 repressed repair of DNA double-strand breaks (DSBs) by HR in a manner partially requiring the ATM/ATR phosphorylation site, serine 15. Cdk-mediated phosphorylation of serine 315 was dispensable for this...

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Identifiers

PMID: 18697815
DOI: 10.1093/nar/gkn503
PMCID: PMC2532731

Genes

ATM
ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Dissecting the role of p53 phosphorylation in homologous recombination provides new clues for gain-of-function mutants.PMID 18697815Read ↗

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