Article
Serine 312 phosphorylation is dispensable for wild-type p53 functions in vivo.
Cell death and differentiation - 1 Feb 2011
Lee M K, Tong W M, Wang Z Q, Sabapathy K
Abstract excerpt
Cellular stimulation results in phosphorylation of the tumor suppressor p53 on multiple residues, though the functional relevance is not always clear. It is noteworthy that the serine (S) 315 residue is unique, as it has been suggested to be phosphorylated not only by genotoxic signals, but also during cell-cycle progression and by endoplasmic-reticulum stress. However, in vitro data have been conflicting as...
Topics
- Amino Acid Sequence
- Amino Acid Substitution
- Animals
- Endoplasmic Reticulum
- Gene Knock-In Techniques
- Genotype
- Mice
- Molecular Sequence Data
- Phosphorylation
- Proto-Oncogene Proteins c-mdm2
- Serine
- Tumor Suppressor Protein p53
- Ubiquitination