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Article

Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair.

Molecular and cellular biology - 1 Jan 2004

Zhang Junran, Willers Henning, Feng Zhihui, Ghosh Jagadish C, Kim Sang, Weaver David T, Chung Jay H, Powell Simon N, Xia Fen

Abstract excerpt

The pathway determining malignant cellular transformation, which depends upon mutation of the BRCA1 tumor suppressor gene, is poorly defined. A growing body of evidence suggests that promotion of DNA double-strand break repair by homologous recombination (HR) may be the means by which BRCA1 maint...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 14701743
DOI: 10.1128/MCB.24.2.708-718.2004
PMCID: PMC343805

Genes

BRCA1
ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14701743-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair.PMID 14701743Read ↗

Chk2 suppresses the oncogenic potential of DNA replication-associated DNA damage.Semantic proximity Read ↗

Plk1 and CK2 Act in Concert to Regulate Rad51 during DNA Double Strand Break RepairSemantic proximity Read ↗

A subset of ATM- and ATR-dependent phosphorylation events requires the BRCA1 protein.Semantic proximity Read ↗

Inhibition of Chk1-dependent G2 DNA damage checkpoint radiosensitizes p53 mutant human cells.Semantic proximity Read ↗

The CHK2–BRCA1 tumour suppressor pathway ensures chromosomal stability in human somatic cellsSemantic proximity Read ↗

BRCA1 is regulated by Chk2 in response to spindle damage.Semantic proximity Read ↗

Regulation of meiotic recombination via Mek1-mediated Rad54 phosphorylation.Semantic proximity Read ↗

Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent Phosphorylation of Chk1 on Ser-317 in Response to Ionizing RadiationSemantic proximity Read ↗

Uterus hyperplasia and increased carcinogen-induced tumorigenesis in mice carrying a targeted mutation of the Chk2 phosphorylation site in Brca1.Semantic proximity Read ↗

RAD51C facilitates checkpoint signaling by promoting CHK2 phosphorylationSemantic proximity Read ↗

Polo-like kinase 1 mediates BRCA1 phosphorylation and recruitment at DNA double-strand breaks.Semantic proximity Read ↗

The Interaction of CtIP and Nbs1 Connects CDK and ATM to Regulate HR–Mediated Double-Strand Break RepairSemantic proximity Read ↗

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