Article
Enhanced phosphorylation of p53 by ATM in response to DNA damage.
Science (New York, N.Y.) - 11 Sept 1998
Banin S, Moyal L, Shieh S, Taya Y, Anderson C W, Chessa L, Smorodinsky N I, Prives C, Reiss Y, Shiloh Y, Ziv Y
Abstract excerpt
The ATM protein, encoded by the gene responsible for the human genetic disorder ataxia telangiectasia (A-T), regulates several cellular responses to DNA breaks. ATM shares a phosphoinositide 3-kinase-related domain with several proteins, some of them protein kinases. A wortmannin-sensitive protei...
Topics
- Adaptor Proteins, Signal Transducing
- Androstadienes
- Ataxia Telangiectasia
- Ataxia Telangiectasia Mutated Proteins
- Carrier Proteins
- Cell Cycle Proteins
- Cell Line
- DNA Damage
- DNA-Binding Proteins
- Enzyme Inhibitors
- Humans
- Mutation
- Phosphatidylinositol 3-Kinases
- Phosphoproteins