BRCA1 phosphorylation by Aurora-A in the regulation of G2 to M transition.

doi:10.1074/jbc.M311780200

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Article

BRCA1 phosphorylation by Aurora-A in the regulation of G2 to M transition.

The Journal of biological chemistry - 7 May 2004

Ouchi Mutsuko, Fujiuchi Nobuko, Sasai Kaori, Katayama Hiroshi, Minamishima Yohji A, Ongusaha Pat P, Deng Chuxia, Sen Subrata, Lee Sam W, Ouchi Toru

Abstract excerpt

Aurora-A/BTAK/STK15 localizes to the centrosome in the G(2)-M phase, and its kinase activity regulates the G(2) to M transition of the cell cycle. Previous studies have shown that the BRCA1 breast cancer tumor suppressor also localizes to the centrosome and that BRCA1 inactivation results in loss of the G(2)-M checkpoint. We demonstrate here that Aurora-A physically binds to and phosphorylates BRCA1. Biochemical...

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PMID: 14990569
DOI: 10.1074/jbc.M311780200

Genes

BRCA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.