Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effect of wild-type, S15D and R175H p53 proteins on DNA end joining in vitro: potential mechanism of DNA double-strand break repair modulation.

Carcinogenesis - 1 Apr 2002

Okorokov Andrei L, Warnock Lorna, Milner Jo

Abstract excerpt

Balanced regulation of DNA double-strand break (DSB) repair is crucial for genetic integrity and cell survival. Cells perform DSB repair either by homologous recombination (HR) or by non-homologous end joining (NHEJ). Either option carries risk for DNA instability. The presence in the cell of the tumour suppressor p53 has been shown to suppress the levels of HR; however, the effect of p53 on DNA EJ is less well...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell-Free System
Share to DNA Damage
Share to DNA Ligases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Repair

Share to Fibroblasts

Share to Genes, p53

Share to Plasmids

Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 11960905
DOI: 10.1093/carcin/23.4.549

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effect of wild-type, S15D and R175H p53 proteins on DNA end joining in vitro: potential mechanism of DNA double-strand break repair modulation.PMID 11960905Read ↗

Involvement of p53 in the repair of DNA double strand breaks: multifaceted Roles of p53 in homologous recombination repair (HRR) and non-homologous end joining (NHEJ).Semantic proximity Read ↗

A role for the p53 tumour suppressor in regulating the balance between homologous recombination and non-homologous end joiningSemantic proximity Read ↗

p53 in recombination and repair.Semantic proximity Read ↗

ATR-p53 restricts homologous recombination in response to replicative stress but does not limit DNA interstrand crosslink repair in lung cancer cells.Semantic proximity Read ↗

Rapid recruitment of p53 to DNA damage sites directs DNA repair choice and integrity.Semantic proximity Read ↗

ERKs and p38 kinase phosphorylate p53 protein at serine 15 in response to UV radiation.Semantic proximity Read ↗

Dissecting the role of p53 phosphorylation in homologous recombination provides new clues for gain-of-function mutants.Semantic proximity Read ↗

DNA-PK promotes DNA end resection at DNA double strand breaks in G0 cellsSemantic proximity Read ↗

Dissociation of p53-mediated suppression of homologous recombination from G1/S cell cycle checkpoint control.Semantic proximity Read ↗

Influence of p53 tumor suppressor protein on bias of DNA repair and apoptotic response in human cells.Semantic proximity Read ↗

Interplay between Ku, Artemis, and the DNA-dependent Protein Kinase Catalytic Subunit at DNA EndsSemantic proximity Read ↗

Identification of the interferon-inducible double-stranded RNA-dependent protein kinase as a regulator of cellular response to bulky adducts.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.