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Article

p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner.

Molecular and cellular biology - 1 Dec 1997

Ko L J, Shieh S Y, Chen X, Jayaraman L, Tamai K, Taya Y, Prives C, Pan Z Q

Abstract excerpt

The tumor suppressor protein p53 acts as a transcriptional activator that can mediate cellular responses to DNA damage by inducing apoptosis and cell cycle arrest. p53 is a nuclear phosphoprotein, and phosphorylation has been proposed to be a means by which the activity of p53 is regulated. The cyclin-dependent kinase (CDK)-activating kinase (CAK) was originally identified as a cellular kinase required for the...

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Source

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Identifiers

PMID: 9372954
DOI: 10.1128/MCB.17.12.7220
PMCID: PMC232579

Genes

CDK7
CDK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner.PMID 9372954Read ↗

The CDK7-cycH-p36 complex of transcription factor IIH phosphorylates p53, enhancing its sequence-specific DNA binding activity in vitro.Semantic proximity Read ↗

p53 C-terminal phosphorylation by CHK1 and CHK2 participates in the regulation of DNA-damage-induced C-terminal acetylation.Semantic proximity Read ↗

Phosphorylation of human p53 on Thr-55.Semantic proximity Read ↗

The C-terminal regulatory domain of p53 contains a functional docking site for cyclin A.Semantic proximity Read ↗

The role of acetylation sites in the regulation of p53 activity.Semantic proximity Read ↗

Dissecting the role of p53 phosphorylation in homologous recombination provides new clues for gain-of-function mutants.Semantic proximity Read ↗

Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress.Semantic proximity Read ↗

Kaposi's Sarcoma-Associated Herpesvirus K-Cyclin Interacts with Cdk9 and Stimulates Cdk9-Mediated Phosphorylation of p53 Tumor SuppressorSemantic proximity Read ↗

Hypoxia activates tumor suppressor p53 by inducing ATR-Chk1 kinase cascade-mediated phosphorylation and consequent 14-3-3γ inactivation of MDMX protein.Semantic proximity Read ↗

ATM engages autodegradation of the E3 ubiquitin ligase COP1 after DNA damage.Semantic proximity Read ↗

Phosphorylation of serines 15 and 37 is necessary for efficient accumulation of p53 following irradiation with UV.Semantic proximity Read ↗

Differential regulation of cyclin-dependent kinase 4 (CDK4) and CDK6, evidence that CDK4 might not be activated by CDK7, and design of a CDK6 activating mutation.Semantic proximity Read ↗

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