Cdk2 kinase phosphorylates serine 315 of human p53 in vitro.

Article

Cdk2 kinase phosphorylates serine 315 of human p53 in vitro.

Oncogene - 6 Jul 1995

Price B D, Hughes-Davies L, Park S J

Abstract excerpt

DNA damage increases p53 protein levels and activates transcription of the p21 gene. The p21 protein binds to and inhibits cdk2 kinase, causing G1 arrest. Here, we have investigated if a p53 fusion protein is a substrate for cdk2 kinase in vitro. Cdk2 kinase was immunoprecipitated from NIH3T3 cel...

Topics

3T3 Cells
Animals
Base Sequence
CDC2-CDC28 Kinases
Cyclin-Dependent Kinase 2
Cyclin-Dependent Kinases
Humans
Mice
Molecular Sequence Data
Mutation
Phosphorylation
Protein Serine-Threonine Kinases
Serine
Tumor Suppressor Protein p53

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